On page 129, Stewart talks about conviction and how creative people value existing knowledge.  I think that is an excellent point.  If an artist is trying to make it big (as we can assume most artists are), paying attention to your existing knowledge of your subject can be the tip of the scale for your success.  If you can hit a niche market that is big enough, or create something that enough people relate to, they will want to share it, and it could spread like wildfire.  Though it is more program than art, Youtube is an example of a company who saw the trends and worked that into their vision.